Popratiloff S A, Weinberg J R, Rustioni A
Institute I of Anatomy, Köln, Germany.
Neuroreport. 1998 Jul 13;9(10):2423-9. doi: 10.1097/00001756-199807130-00049.
We previously demonstrated a predominance of contacts by one type of glomerular ending (presumably from unmyelinated fibers) upon postsynaptic sites expressing the GluR1 subunit of the AMPA receptor, and of contacts by another type of glomerular ending (presumably from small myelinated fibers) upon postsynaptic sites expressing GLuR2. We here investigate whether any one of three types of primary afferent terminals, two glomerular and one non-glomerular, have direct contacts with postsynaptic sites containing the NMDAR1 subunit. Counts of gold particles revealed that contacts by primary afferents with NMDAR1-positive sites were less frequent than in material processed for AMPA receptor subunits, but that all three types of terminals contact NMDAR1-immunopositive postsynaptic sites in about equal proportions.
我们先前证明，一种类型的肾小球终末（可能来自无髓纤维）在表达AMPA受体GluR1亚基的突触后位点上的接触占主导地位，而另一种类型的肾小球终末（可能来自小的有髓纤维）在表达GluR2的突触后位点上的接触占主导地位。我们在此研究三种类型的初级传入终末（两种肾小球型和一种非肾小球型）中的任何一种是否与含有NMDAR1亚基的突触后位点有直接接触。金颗粒计数显示，初级传入神经与NMDAR1阳性位点的接触比处理AMPA受体亚基的材料中要少，但所有三种类型的终末与NMDAR1免疫阳性的突触后位点的接触比例大致相等。
