Shinkai T, Ohmori O, Kojima H, Terao T, Suzuki T, Abe K
Department of Psychiatry, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Hum Hered. 1998 Jul-Aug;48(4):212-5. doi: 10.1159/000022803.
Serotonin (5-hydroxytryptamine, 5-HT) may play an important role in the pathogenesis of schizophrenia. Previous studies suggested that the efficacy of atypical neuroleptic drugs (e.g., risperidone and clozapine) on negative symptoms may be related to the 5-HT2a receptor. Although association studies between MspI polymorphism (T102C) and the 5-HT2a receptor gene and schizophrenia have been reported, their results are still controversial. The aim of this study was to examine the association between T102C polymorphism of the 5-HT2a receptor gene and schizophrenia as well as the association between the polymorphism and negative symptoms in a Japanese population (106 patients with schizophrenia and 109 healthy controls). No significant positive associations were observed. Our results suggest that the 5-HT2a receptor gene is not involved in the pathogenesis of schizophrenia or negative symptoms.
血清素（5-羟色胺，5-HT）可能在精神分裂症的发病机制中起重要作用。先前的研究表明，非典型抗精神病药物（如利培酮和氯氮平）对阴性症状的疗效可能与5-HT2a受体有关。尽管已有报道MspI多态性（T102C）与5-HT2a受体基因和精神分裂症之间的关联研究，但其结果仍存在争议。本研究的目的是在日本人群（106例精神分裂症患者和109名健康对照）中检测5-HT2a受体基因的T102C多态性与精神分裂症之间的关联以及该多态性与阴性症状之间的关联。未观察到显著的正相关。我们的结果表明，5-HT2a受体基因不参与精神分裂症或阴性症状的发病机制。
