基于测序的分型揭示了六个新的主要组织相容性复合体I类链相关基因B（MICB）等位基因。
Sequencing-based typing reveals six novel MHC class I chain-related gene B (MICB) alleles.
作者信息
Visser C J, Tilanus M G, Schaeffer V, Tatari Z, Tamouza R, Janin A, Charron D
机构信息
Department of Immunology and Histocompatibility, Hôpital Saint Louis, Paris, France.
出版信息
Tissue Antigens. 1998 Jun;51(6):649-52. doi: 10.1111/j.1399-0039.1998.tb03008.x.
The MHC class I chain-related gene A (MICA) is highly polymorphic. In this paper we demonstrate polymorphism in the other expressing member of the MIC family of genes: MICB. Using a sequencing-based typing approach on cDNA, analysis of exons 2 through 6 revealed eight polymorphic sites resulting in six unique MICB sequences. Although MICB has high nucleotide homology with MICA, its polymorphism is restricted and at different sites compared to those in MICA.
主要组织相容性复合体I类链相关基因A（MICA）具有高度多态性。在本文中，我们证明了MIC基因家族的另一个表达成员：MICB也存在多态性。通过对cDNA采用基于测序的分型方法，对第2至6外显子的分析揭示了8个多态性位点，产生了6种独特的MICB序列。尽管MICB与MICA具有高度的核苷酸同源性，但其多态性受到限制，且与MICA的多态性位点不同。
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