Plas D R, Thomas M L
Center for Immunology, Department of Pathology, Washington University, St. Louis, MO 63110, USA.
J Mol Med (Berl). 1998 Jul;76(8):589-95. doi: 10.1007/s001090050254.
The negative regulation of antigen receptor signal transduction is essential for the maintenance of thresholds for activation in lymphocytes. CD45 and SHP-1 are tyrosine phosphatases that are important in maintaining the proper level of tyrosine phosphorylation. Regulation of the src family of tyrosine kinases is mediated by the coordinated action of the tyrosine kinase Csk and the tyrosine phosphatase CD45. B cell receptor signaling is negatively regulated by the recruitment of SHP-1 to bind the B cell transmembrane proteins CD22 and FcgammaRIIb1. SHP-1 also functions to negatively regulate T cell receptor signaling by dephosphorylating and inactivating tyrosine kinases.
抗原受体信号转导的负调控对于维持淋巴细胞激活阈值至关重要。CD45和SHP-1是酪氨酸磷酸酶，在维持酪氨酸磷酸化的适当水平方面很重要。酪氨酸激酶Csk和酪氨酸磷酸酶CD45的协同作用介导了src家族酪氨酸激酶的调节。SHP-1通过募集与B细胞跨膜蛋白CD22和FcγRIIb1结合来负调控B细胞受体信号。SHP-1还通过使酪氨酸激酶去磷酸化并使其失活来负调控T细胞受体信号。
