Vinson G P, Ho M M
Department of Biochemistry, Queen Mary and Westfield College, London, UK.
Horm Metab Res. 1998 Jun-Jul;30(6-7):355-9. doi: 10.1055/s-2007-978898.
The tissue renin angiotensin systems (RAS) may have specific roles that complement those of the systemic RAS. In the adrenal, the tissue RAS has been implicated in the regulation of glomerulosa tissue growth and function, and in mediating the response of the tissue to stimulation. Using in situ hybridisation methods, it was demonstrated that transcription of the (pro)renin gene is regulated by sodium status, and is increased specifically in the zona glomerulosa by a low sodium diet. When captopril was added to incubations of capsule/glomerulosa fractions, stimulation of aldosterone by angiotensin II was enhanced. The data suggest that the rat adrenal cortex, and specifically the zona glomerulosa, may be chronically stimulated by angiotensin II generated within the tissue itself.
组织肾素-血管紧张素系统（RAS）可能具有补充全身RAS的特定作用。在肾上腺中，组织RAS参与调节球状带组织的生长和功能，并介导组织对刺激的反应。采用原位杂交方法表明，（前）肾素基因的转录受钠状态调节，低钠饮食可使球状带中的转录特异性增加。当卡托普利添加到被膜/球状带组分的孵育体系中时，血管紧张素II对醛固酮的刺激作用增强。这些数据表明，大鼠肾上腺皮质，特别是球状带，可能受到组织自身产生的血管紧张素II的长期刺激。
