Fienberg A A, Hiroi N, Mermelstein P G, Song W, Snyder G L, Nishi A, Cheramy A, O'Callaghan J P, Miller D B, Cole D G, Corbett R, Haile C N, Cooper D C, Onn S P, Grace A A, Ouimet C C, White F J, Hyman S E, Surmeier D J, Girault J, Nestler E J, Greengard P
Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA.
Science. 1998 Aug 7;281(5378):838-42. doi: 10.1126/science.281.5378.838.
Dopaminergic neurons exert a major modulatory effect on the forebrain. Dopamine and adenosine 3',5'-monophosphate-regulated phosphoprotein (32 kilodaltons) (DARPP-32), which is enriched in all neurons that receive a dopaminergic input, is converted in response to dopamine into a potent protein phosphatase inhibitor. Mice generated to contain a targeted disruption of the DARPP-32 gene showed profound deficits in their molecular, electrophysiological, and behavioral responses to dopamine, drugs of abuse, and antipsychotic medication. The results show that DARPP-32 plays a central role in regulating the efficacy of dopaminergic neurotransmission.
多巴胺能神经元对前脑发挥主要的调节作用。多巴胺和3',5'-环磷酸腺苷调节的磷蛋白（32千道尔顿）（DARPP-32）在所有接受多巴胺能输入的神经元中含量丰富，它会响应多巴胺转化为一种强效的蛋白磷酸酶抑制剂。生成的含有DARPP-32基因靶向缺失的小鼠在对多巴胺、滥用药物和抗精神病药物的分子、电生理及行为反应方面表现出严重缺陷。结果表明，DARPP-32在调节多巴胺能神经传递的效能中起核心作用。
