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[脂质过氧化作用以及季铵化合物在使该过程正常化中的作用]

[Lipid peroxidation and the role of quaternary ammonium compounds in normalizing this process].

作者信息

Pis'ko G T, Kolomoets M Iu, Meshchishen I F, Vasiliuk V N

出版信息

Lik Sprava. 1998 May(3):52-6.

PMID:9695564
Abstract

Regulation of lipid peroxidation is realized not only by antioxidant enzymes but by natural antioxidants as well. We have lately succeeded, together with the students, in identifying antioxidant properties of quaternary ammonium compounds, which fact makes it possible for the above properties to gain extensive applicability in a setting where there is this variety of disbolism. One of such drug preparations is ethonium. The article contains information about uses of ethonium in the tablet dose form. The tablets are of little toxicity, they stimulate the oxidation-reduction processes and proved to be effective in experimental gastric and duodenal ulcers.

摘要

脂质过氧化的调节不仅通过抗氧化酶来实现,天然抗氧化剂也能起到调节作用。最近,我们和学生们成功鉴定出季铵化合物的抗氧化特性,这使得上述特性在存在多种新陈代谢的环境中能够得到广泛应用。乙胺碘呋酮就是这类药物制剂之一。本文包含了乙胺碘呋酮片剂剂型的用途信息。这些片剂毒性很小,能刺激氧化还原过程,并且在实验性胃溃疡和十二指肠溃疡中已证明是有效的。

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