Vorobĭova L R
Lik Sprava. 1998 May(3):87-90.
With the purpose of establishing morphogenetic features of precancer and early cancer of the prostate gland a comparative immunomorphological evaluation was done of the prostate tumor markers (PAP, PSA, PCNA, and 34 beta E12). Due emphasis is given to the part the basal cell dysplasia plays in morphogenesis of prostatic cancer. The precancer lesions of the prostate include atypical adenomatous hyperplasia, grade I and II prostatic intraepithelial neoplasia (PIN). Grade III prostatic intraepithelial neoplasm is cancer in situ, or uninfiltrative (unpalpable) cancer of the prostate. PIN patients are at high risk for subsequent development of invasive prostatic carcinoma.
为了确定前列腺癌前病变和早期癌的形态发生特征，对前列腺肿瘤标志物（前列腺酸性磷酸酶、前列腺特异性抗原、增殖细胞核抗原和34βE12）进行了比较免疫形态学评估。重点关注基底细胞发育异常在前列腺癌形态发生中所起的作用。前列腺的癌前病变包括非典型腺瘤样增生、I级和II级前列腺上皮内瘤变（PIN）。III级前列腺上皮内瘤变是原位癌，即前列腺的非浸润性（不可触及）癌。PIN患者后续发生浸润性前列腺癌的风险很高。
