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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Sever P S, Dring L G, Williams R T

Xenobiotica. 1976 Jun;6(6):345-53. doi: 10.3109/00498257609151646.

The metabolism of (+/-)-p-hydroxy[14C]amphetamine has been studied in the rat, guinea-pig and man. 2. Most of the administered 14C was excreted in the urine within the first 24 h (64-92%), and was present mainly as free and conjugated p-hydroxy[14C]-amphetamine. In the female rat and female guinea-pig the conjugate was a glucuronide, but in man, who received a much smaller dose, the conjugate was a sulphate ester. A sex difference in conjugation was found in the rat, the female partly conjugating the drug but not the male. 3. Small quantities (1-6% of dose) of p-hydroxynorephedrine, a putative false neurotransmitter, were found in the urine of the three species. 4. Some oxidative degradation of the side chain of p-hydroxyamphetamine occurred in rat and guinea-pig since small amounts of p-hydroxybenzoic acid (1-3%) were detected in the urine.

已在大鼠、豚鼠和人体中研究了（±）-对羟基[¹⁴C]苯丙胺的代谢情况。2. 大部分给予的¹⁴C在最初24小时内通过尿液排出（64 - 92%），并且主要以游离和结合的对羟基[¹⁴C]苯丙胺形式存在。在雌性大鼠和雌性豚鼠中，结合物是葡糖醛酸苷，但在接受剂量小得多的人体中，结合物是硫酸酯。在大鼠中发现了结合方面的性别差异，雌性部分地使药物结合而雄性则不然。3. 在这三个物种的尿液中发现了少量（剂量的1 - 6%）对羟基去甲麻黄碱，一种假定的假性神经递质。4. 在大鼠和豚鼠中，对羟基苯丙胺侧链发生了一些氧化降解，因为在尿液中检测到了少量的对羟基苯甲酸（1 - 3%）。

Sever P S, Dring L G, Williams R T

Xenobiotica. 1976 Jun;6(6):345-53. doi: 10.3109/00498257609151646.

The metabolism of (+/-)-p-hydroxy[14C]amphetamine has been studied in the rat, guinea-pig and man. 2. Most of the administered 14C was excreted in the urine within the first 24 h (64-92%), and was present mainly as free and conjugated p-hydroxy[14C]-amphetamine. In the female rat and female guinea-pig the conjugate was a glucuronide, but in man, who received a much smaller dose, the conjugate was a sulphate ester. A sex difference in conjugation was found in the rat, the female partly conjugating the drug but not the male. 3. Small quantities (1-6% of dose) of p-hydroxynorephedrine, a putative false neurotransmitter, were found in the urine of the three species. 4. Some oxidative degradation of the side chain of p-hydroxyamphetamine occurred in rat and guinea-pig since small amounts of p-hydroxybenzoic acid (1-3%) were detected in the urine.

已在大鼠、豚鼠和人体中研究了（±）-对羟基[¹⁴C]苯丙胺的代谢情况。2. 大部分给予的¹⁴C在最初24小时内通过尿液排出（64 - 92%），并且主要以游离和结合的对羟基[¹⁴C]苯丙胺形式存在。在雌性大鼠和雌性豚鼠中，结合物是葡糖醛酸苷，但在接受剂量小得多的人体中，结合物是硫酸酯。在大鼠中发现了结合方面的性别差异，雌性部分地使药物结合而雄性则不然。3. 在这三个物种的尿液中发现了少量（剂量的1 - 6%）对羟基去甲麻黄碱，一种假定的假性神经递质。4. 在大鼠和豚鼠中，对羟基苯丙胺侧链发生了一些氧化降解，因为在尿液中检测到了少量的对羟基苯甲酸（1 - 3%）。