Chebili S, Abaoub A, Mezouane B, Le Goff J F
Psychiatre des Hôpitaux, EPS Ville Evrard, Neuilly-sur-Marne.
Encephale. 1998 May-Jun;24(3):180-4.
The purpose of this study is to correlate antidepressant treatment with sexual stimulation. The first part of this paper tries to describe some physiologic aspects of the sexual function. This complex subject includes several neuromediators which belong to adrenergic, cholinergic, dopaminergic and serotoninergic systems. A double-blind study shows that viloxazine, an atypical antidepressant, could act specifically on sex drive by desinhibiting effect. A precise study concludes that moclobemide improve significantly all components of sexual function. The numerous side effects of doxépine is a hindrance to its prescription. More precise studies about viloxazine and moclobemide suggest that both could have a specific effect on different components of sexual activity. In the second part of this paper, we consider the concept of "corrector". These drugs are numerous, however their prescriptions are not very wide spread: yohimbine, cyproheptadine, amantadine, bethanechol.
本研究的目的是将抗抑郁治疗与性刺激相关联。本文的第一部分试图描述性功能的一些生理方面。这个复杂的主题包括几种属于肾上腺素能、胆碱能、多巴胺能和血清素能系统的神经介质。一项双盲研究表明,一种非典型抗抑郁药维洛沙嗪可通过去抑制作用特异性作用于性欲。一项精确研究得出结论,吗氯贝胺可显著改善性功能的所有组成部分。多塞平的众多副作用妨碍了其处方应用。关于维洛沙嗪和吗氯贝胺的更精确研究表明,两者可能对性活动的不同组成部分有特异性作用。在本文的第二部分,我们考虑“校正剂”的概念。这类药物有很多,但它们的处方应用并不广泛:育亨宾、赛庚啶、金刚烷胺、氨甲酰甲胆碱。