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Detection of carcinoembryonic antigen mRNA in the mesenteric vein of patients with resectable colorectal cancer.

作者信息

Ueda T, Furui J, Komuta K, Yamaguchi J, Yamamoto M, Furukawa K, Kanematsu T

机构信息

Department of Surgery II, Nagasaki University School of Medicine, Japan.

出版信息

Surg Today. 1998;28(7):701-6. doi: 10.1007/BF02484615.

DOI:10.1007/BF02484615
PMID:9697262
Abstract

The detection of tumor cells in the drainage venous blood of patients with colorectal cancer was made feasible by demonstrating carcinoembryonic antigen (CEA) mRNA in the mononuclear cell component of the blood, using a nested reverse transcription-polymerase chain reaction. CEA mRNA was detected in the drainage venous blood from 11 (42%) of 26 patients, and the rate of detection increased according to the grade of vessel invasion. CEA mRNA was detected in all patients with synchronous liver metastases, even though there was no significant correlation between the presence of CEA mRNA in the drainage venous blood and the clinicopathological findings. As the presence of CEA mRNA in the drainage venous blood is an indicator of the spread of tumor cells in patients with colorectal cancer, this assay can be used to assess the possible outcome of patients with colorectal cancer, providing one more tool for the physician-oncologist to use in designing appropriate treatments.

摘要

相似文献

1
Detection of carcinoembryonic antigen mRNA in the mesenteric vein of patients with resectable colorectal cancer.
Surg Today. 1998;28(7):701-6. doi: 10.1007/BF02484615.
2
Carcinoembryonic antigen mRNA in the mesenteric vein is not a predictor of hepatic metastasis in patients with resectable colorectal cancer: a long-term study.肠系膜静脉中癌胚抗原mRNA并非可切除结直肠癌患者肝转移的预测指标：一项长期研究
Dis Colon Rectum. 2003 Dec;46(12):1653-8. doi: 10.1007/BF02660771.
3
Usefulness and clinical significance of quantitative real-time RT-PCR to detect isolated tumor cells in the peripheral blood and tumor drainage blood of patients with colorectal cancer.定量实时逆转录聚合酶链反应检测结直肠癌患者外周血和肿瘤引流血中孤立肿瘤细胞的实用性及临床意义
Int J Oncol. 2006 Feb;28(2):297-306.
4
Detection of blood-borne cells in colorectal cancer patients by nested reverse transcription-polymerase chain reaction for carcinoembryonic antigen messenger RNA: longitudinal analyses and demonstration of its potential importance as an adjunct to multiple serum markers.通过巢式逆转录聚合酶链反应检测结直肠癌患者血源细胞中的癌胚抗原信使核糖核酸：纵向分析及其作为多种血清标志物辅助手段的潜在重要性的论证
Cancer Res. 2001 Mar 15;61(6):2523-32.
5
Prognostic significance of reverse transcriptase-polymerase chain reaction measurement of carcinoembryonic antigen mRNA levels in tumor drainage blood and peripheral blood of patients with colorectal carcinoma.逆转录聚合酶链反应检测结直肠癌患者肿瘤引流血和外周血中癌胚抗原mRNA水平的预后意义
Cancer. 2000 Sep 1;89(5):970-6.
6
Molecular detection of circulating tumor cells in the peripheral blood of patients with colorectal cancer using RT-PCR: significance of the prediction of postoperative metastasis.应用逆转录聚合酶链反应检测结直肠癌患者外周血循环肿瘤细胞：对术后转移预测的意义
World J Surg. 2006 Jun;30(6):1007-13. doi: 10.1007/s00268-005-0485-z.
7
CEA mRNA identification in peripheral blood is feasible for colorectal, but not for gastric or pancreatic cancer staging.外周血中癌胚抗原信使核糖核酸的鉴定对结直肠癌分期可行，但对胃癌或胰腺癌分期不可行。
Oncology. 2000 Nov;59(4):323-8. doi: 10.1159/000012190.
8
Clinical impact of carcinoembryonic antigen messenger ribonucleic acid expression in tumor-draining vein blood on postoperative liver metastasis in patients with colorectal carcinoma: a prospective, cohort study.结直肠癌患者肿瘤引流静脉血中癌胚抗原信使核糖核酸表达对术后肝转移的临床影响：一项前瞻性队列研究
Dis Colon Rectum. 2003 Apr;46(4):467-73. doi: 10.1007/s10350-004-6584-3.
9
Detection of tumor cell contamination in peripheral blood by RT-PCR in gastrointestinal cancer patients.通过逆转录聚合酶链反应检测胃肠道癌患者外周血中的肿瘤细胞污染
J Korean Med Sci. 1999 Dec;14(6):623-8. doi: 10.3346/jkms.1999.14.6.623.
10
Detection of colonic cells in peripheral blood of colorectal cancer patients by means of reverse transcriptase and polymerase chain reaction.通过逆转录酶和聚合酶链反应检测结直肠癌患者外周血中的结肠细胞。
Br J Cancer. 1998 Nov;78(10):1368-72. doi: 10.1038/bjc.1998.686.

引用本文的文献

1
Detection of carcinoembryonic antigen messenger RNA in blood using quantitative real-time reverse transcriptase-polymerase chain reaction to predict recurrence of gastric adenocarcinoma.应用实时荧光定量逆转录聚合酶链反应检测血中癌胚抗原信使 RNA 预测胃腺癌的复发。
J Transl Med. 2010 Oct 31;8:107. doi: 10.1186/1479-5876-8-107.
2
The serum level of carcinoembryonic antigen in drainage venous blood is not a sensitive predictor of metachronous hepatic metastasis for patients with colorectal cancer.结直肠癌患者引流静脉血中癌胚抗原水平不能敏感预测肝转移的发生。
Surg Today. 2010 Aug;40(8):745-51. doi: 10.1007/s00595-009-4205-4. Epub 2010 Jul 30.
3

本文引用的文献

1
The cytologic demonstration and significance of tumor cells in the mesenteric venous blood in patients with colorectal carcinoma.结直肠癌患者肠系膜静脉血中肿瘤细胞的细胞学显示及其意义
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The clinical significance of invasion of veins by rectal cancer.直肠癌侵犯静脉的临床意义。
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Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures.抗生物素蛋白-生物素-过氧化物酶复合物（ABC）在免疫过氧化物酶技术中的应用：ABC法与未标记抗体（PAP）法的比较。
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