Lipitz S, Yagel S, Malinger G, Meizner I, Zalel Y, Achiron R
Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Tel Hashomer, Israel.
Ultrasound Obstet Gynecol. 1998 Jul;12(1):23-6. doi: 10.1046/j.1469-0705.1998.12010023.x.
To evaluate the outcome of fetuses with isolated borderline, unilateral ventriculomegaly.
A retrospective survey was conducted at four perinatal centers in Israel.
Only fetuses with one ventricular width of > or = 11 mm and the other < 10 mm were included in the study. In all cases, the difference of the ventricular width between the two ventricles was > 2.4 mm (two standard deviations). Fetuses with other malformations, chromosomal abnormalities, or those with evidence of in utero infection, were not included in the study.
Unilateral ventriculomegaly was found in 27 subjects (after excluding one case with unilateral ventriculomegaly and Down's syndrome). The mean width of the enlarged ventricle was 11.7 +/- 0.9 mm, while the other normal ventricle was 7.2 +/- 0.9 mm. The mean gestational age at diagnosis of the unilateral ventriculomegaly was 23.6 +/- 2.7 weeks. In one case, pregnancy was terminated, and pathological examination of the fetal brain failed to detect any structural abnormality. Twenty-five patients delivered at term and only one at 34 weeks' gestation. The neurological development in all 25 fetuses was normal, and one fetus had petit mal seizures.
Fetuses with isolated, borderline unilateral ventriculomegaly, but without other abnormalities, have a good neurological outcome.
评估孤立性临界性单侧脑室扩大胎儿的预后情况。
在以色列的四个围产期中心进行了一项回顾性调查。
本研究仅纳入一侧脑室宽度≥11mm且另一侧<10mm的胎儿。所有病例中，两侧脑室宽度差值>2.4mm（两个标准差）。伴有其他畸形、染色体异常或有宫内感染证据的胎儿不纳入本研究。
共发现27例单侧脑室扩大胎儿（排除1例单侧脑室扩大合并唐氏综合征的病例）。扩大脑室的平均宽度为11.7±0.9mm，另一侧正常脑室为7.2±0.9mm。诊断单侧脑室扩大时的平均孕周为23.6±2.7周。1例终止妊娠，胎儿脑部病理检查未发现任何结构异常。25例足月分娩，1例在孕34周分娩。25例胎儿神经发育均正常，1例有失神发作。
孤立性临界性单侧脑室扩大但无其他异常的胎儿，神经预后良好。
