Balish E, Wagner R D, Vázquez-Torres A, Pierson C, Warner T
University of Wisconsin Medical School, Department of Medical Microbiology, Madison 53706-1532, USA.
J Infect Dis. 1998 Aug;178(2):478-87. doi: 10.1086/515645.
Germ-free C57BL/6 x 129 interferon-gamma knockout (IFN-gamma(-/-)) mice and their immunocompetent (+/-, +/+) counterparts were colonized with a pure culture of Candida albicans to assess their natural susceptibility to mucosal and systemic candidiasis of endogenous origin. Colonization with a pure culture of C. albicans was not lethal for adult or neonatal IFN-gamma(-/-) gnotobiotic mice over the 15-week study. The IFN-gamma(-/-) mice were more susceptible to gastric (cardia-antrum section), anorectal, and acute systemic (intravenous challenge) candidiasis than immunocompetent controls, and some IFN-gamma(-/-) mice developed intestinal adenomas after colonization with C. albicans. The enhanced susceptibility of IFN-gamma(-/-) mice, compared with immunocompetent controls, may be associated with a poor proliferative response of spleen cells to C. albicans antigens and a T helper 2 (IgG1) serum antibody response to C. albicans antigens. Thus, IFN-gamma is important for murine resistance to gastric, anorectal, and acute systemic candidiasis.
无菌C57BL/6×129干扰素-γ基因敲除（IFN-γ(-/-)）小鼠及其具有免疫活性的（+/-、+/+)同窝小鼠用白色念珠菌纯培养物进行定殖，以评估它们对内源性黏膜和全身性念珠菌病的天然易感性。在为期15周的研究中，用白色念珠菌纯培养物进行定殖对成年或新生IFN-γ(-/-)无菌小鼠并不致命。与具有免疫活性的对照相比，IFN-γ(-/-)小鼠对胃部（贲门-胃窦部）、肛门直肠和急性全身性（静脉内攻击）念珠菌病更易感，并且一些IFN-γ(-/-)小鼠在用白色念珠菌定殖后发生了肠道腺瘤。与具有免疫活性的对照相比，IFN-γ(-/-)小鼠易感性增强可能与脾细胞对白色念珠菌抗原的增殖反应不佳以及对白色念珠菌抗原的辅助性T细胞2（IgG1）血清抗体反应有关。因此，IFN-γ对小鼠抵抗胃部、肛门直肠和急性全身性念珠菌病很重要。
