Eulenburg F, Bode C
Z Gastroenterol. 1976 May;14(3):354-64.
Four choleretics, selected at random from the German list of medical preparations, were tested with regards to their influence on hepatic bile production and bile composition. The investigations were performed on patients with a T-drainage in the ductus choledochus after bile duct revision. Bile was collected after fasting (90 min) and after administration of the drugs to be tested (3 hours). The choleretics were administered orally in a dosage two to five times more than the recommended one. Besides the bile volume bile acids, cholesterol, bilirubin, bicarbonate, potassium, sodium and calcium were determined. None of the parameters could be definitely influenced by these drugs. On the other hand a pronounced increase in the bile flow as well as the expected change in the other parameters could be observed after standardized secretion-stimulation which had been additionally carried out in half of the patients (dehydrocholic acid, i.v., taurocholic acid intraduodenally, secretin i.v., meals).
从德国药品清单中随机选取了四种利胆剂，测试它们对肝胆汁生成和胆汁成分的影响。研究对象为胆管修复术后胆总管置T管引流的患者。在禁食（90分钟）后以及给予受试药物（3小时）后采集胆汁。所给利胆剂的口服剂量是推荐剂量的二至五倍。除了胆汁量，还测定了胆汁酸、胆固醇、胆红素、碳酸氢盐、钾、钠和钙。这些药物均未对任何参数产生明确影响。另一方面，在一半患者中额外进行了标准化分泌刺激（静脉注射去氢胆酸、十二指肠内注射牛磺胆酸、静脉注射促胰液素、进食）后，可观察到胆汁流量显著增加以及其他参数出现预期变化。
