Hwang S J, Park H, Park K
Purdue University, School of Pharmacy, West Lafayette, IN 47907, USA.
Crit Rev Ther Drug Carrier Syst. 1998;15(3):243-84.
The development of a long-term oral controlled-release dosage form has been difficult mainly because of the transit of the dosage form through the gastrointestinal (GI) tract. Several approaches to extend gastric residence time have been tried. The most commonly used systems are (1) intragastric floating systems, (2) high-density systems, (3) mucoadhesive systems, (4) magnetic systems, (5) unfoldable, extendible, or swellable systems, and (6) superporous hydrogel systems. The concept of each approach is examined, and improvements that are needed for further development are discussed. Background materials in the GI physiology that are necessary for understanding the concept and usefulness of each approach are also provided.
长期口服控释剂型的开发一直很困难，主要原因是该剂型在胃肠道中的转运过程。人们已经尝试了几种延长胃滞留时间的方法。最常用的系统有：（1）胃内漂浮系统；（2）高密度系统；（3）粘膜粘附系统；（4）磁性系统；（5）不可折叠、可伸展或可膨胀系统；（6）超多孔水凝胶系统。对每种方法的概念进行了研究，并讨论了进一步开发所需的改进。还提供了理解每种方法的概念和实用性所必需的胃肠道生理学背景材料。
