Sugimoto H, Hashimoto N, Suzuki S, Gejyo F
Central Clinical Laboratory, Fukui Medical University, Japan.
Tohoku J Exp Med. 1998 Apr;184(4):311-6. doi: 10.1620/tjem.184.311.
To clarify the serum levels of soluble interleukin-2 receptor (sIL-2R) in patients with renal diseases, we examined 281 patients without various renal diseases with or without systemic disease (including 197 patients without systemic diseases and 84 patients with systemic diseases). The sIL-2R level was significantly higher in patients with renal diseases, than in healthy volunteers. In the group of renal diseases, the sIL-2R level in patients with rapidly progressive nephritic syndrome was especially higher than in patients with other renal diseases. In patients without systemic diseases, the serum level of sIL-2R was significantly and positively correlated with the urinary excretion of protein, and the serum levels of creatinine and uric acid, and was negatively correlated with the glomerular filtration rate (GFR). In the patients with systemic diseases, the correlation between the serum levels of sIL-2R and the serum levels of creatinine or GFR were not as strong as observed in the patients without systemic diseases. The serum level of sIL-2R was outside the normal range in patients with systemic diseases with a serum level of creatinine above 2.0 mg/100 ml. These findings suggest that the serum levels of sIL-2R in patients with renal disease may increase and correlate with the impaired renal function, that he increased sIL-2R levels in patients with systemic diseases may be dependent on the activity of systemic disease, and that it may be not useful indicator of diseases activity in patients with systemic diseases when the serum level of creatinine was above 2.0 mg/100 ml.
为明确肾病患者血清可溶性白细胞介素-2受体（sIL-2R）水平，我们对281例无各种肾病、伴或不伴有全身性疾病的患者进行了检查（包括197例无全身性疾病的患者和84例有全身性疾病的患者）。肾病患者的sIL-2R水平显著高于健康志愿者。在肾病组中，快速进行性肾炎综合征患者的sIL-2R水平尤其高于其他肾病患者。在无全身性疾病的患者中，sIL-2R血清水平与尿蛋白排泄、血清肌酐和尿酸水平呈显著正相关，与肾小球滤过率（GFR）呈负相关。在有全身性疾病的患者中，sIL-2R血清水平与血清肌酐水平或GFR之间的相关性不如在无全身性疾病的患者中那么强。血清肌酐水平高于2.0mg/100ml的全身性疾病患者，其sIL-2R血清水平超出正常范围。这些发现提示，肾病患者的sIL-2R血清水平可能升高并与肾功能损害相关，全身性疾病患者sIL-2R水平升高可能取决于全身性疾病的活动情况，并且当血清肌酐水平高于2.0mg/100ml时，它可能不是全身性疾病患者疾病活动的有用指标。
