Bock C, Krep H, Brinker G, Hoehn-Berlage M
Max-Plank-Institute for Neurological Research, Cologne, Germany.
NMR Biomed. 1998 May;11(3):115-9. doi: 10.1002/(sici)1099-1492(199805)11:3<115::aid-nbm526>3.0.co;2-k.
T2*-weighted imaging at 4.7 T was used to identify the cortical areas activated by electrical stimulation of the forepaw and hindpaw of alpha-chloralose anesthetized rats. Variation of the coronal slice position relative to the bregma, showed that the forepaw representation in the somatosensory cortex is more frontal and lateral than that of the hindpaw. Overlap between both activation areas was observed only in a small region in the slice at the level of the bregma. Documented localizations of both representations are in good agreement with earlier observations using invasive techniques. The determination of the separate areas of both paws indicates the feasibility of more complex activation studies in anesthetized animals, such as combined stimulations for the investigation of potentiation or depression effects on individual stimuli.
采用4.7T的T2*加权成像来识别由电刺激α-氯醛糖麻醉大鼠的前爪和后爪所激活的皮质区域。相对于前囟的冠状切片位置的变化表明，体感皮层中的前爪表征比后爪表征更靠前且更靠外侧。仅在位于前囟水平的切片中的一个小区域观察到两个激活区域之间的重叠。两种表征的记录定位与早期使用侵入性技术的观察结果高度一致。确定两只爪子的单独区域表明在麻醉动物中进行更复杂的激活研究是可行的，例如联合刺激以研究对单个刺激的增强或抑制作用。
