Büttner H H, Göretzlehner G, Rudolf K
Zentralbl Gynakol. 1976;98(15):914-8.
48 fertile women took in three weeks 1 mg ethinylestradiolsulfonate weekly and in the 4th week 10 mg norethisterone acetate, respectively d-norgestrel in different dosages (0,5 mgs, 1,0 mgs, 1,5 mgs or 3,0 mgs). On this 48 women 69 abrasiones were made between the first and 37th treatment cycles in order to estimate the endometrium. Ethinylestradiolsulfonate caused for the most part a proliferation of endometrium, which reached to a glandulare cystic hyperplastic endometrium. We did not observe a reduction of the endometrial respond to this depot-estrogen in dependence on the time of taking. Norethisterone acetate and d-norgestrel effected on a different proliferated endometrium a secretory transfer mation always.
48名育龄妇女在三周内每周服用1毫克炔雌醇磺酸盐，在第4周分别服用10毫克醋酸炔诺酮或不同剂量（0.5毫克、1.0毫克、1.5毫克或3.0毫克）的d-炔诺孕酮。为评估子宫内膜，在这48名妇女的第1至37个治疗周期之间进行了69次刮宫。炔雌醇磺酸盐大多引起子宫内膜增生，发展为腺囊性增生性子宫内膜。我们未观察到子宫内膜对这种长效雌激素的反应因服药时间而降低。醋酸炔诺酮和d-炔诺孕酮总是使不同程度增生的子宫内膜发生分泌转化。
