Rattner J B, Mack G J, Fritzler M J
Department of Anatomy, The University of Calgary, AB, Canada.
Mol Biol Rep. 1998 Jul;25(3):143-55. doi: 10.1023/a:1016523013819.
Autoantibodies directed to a variety of cellular antigens and organelles are a feature of autoimmune diseases. They have proven useful in a clinical setting to establish diagnosis, estimate prognosis, follow disease progression, alter therapy, and initiate new investigations. Cellular and molecular biologists have used autoantibodies as probes to identify molecules involved in key cellular processes. One of the most interesting sets of autoantibodies are those that target antigens within the mitotic apparatus (MA). The MA includes chromosomes, spindle microtubules and centrosomes. The identification, localization, function, and clinical relevance of MA autoantigens is the focus of this review.
针对多种细胞抗原和细胞器的自身抗体是自身免疫性疾病的一个特征。它们已被证明在临床环境中有助于建立诊断、评估预后、跟踪疾病进展、调整治疗方案以及开展新的研究。细胞生物学家和分子生物学家已将自身抗体用作探针来识别参与关键细胞过程的分子。最有趣的一组自身抗体是那些靶向有丝分裂装置（MA）内抗原的抗体。MA包括染色体、纺锤体微管和中心体。MA自身抗原的识别、定位、功能及临床相关性是本综述的重点。
