Staron K, Samuels D S
Institute of Biochemistry, Warsaw University, Poland.
Mol Biol Rep. 1998 Jul;25(3):157-61. doi: 10.1023/a:1006827925817.
Eukaryotic topoisomerase I polypeptides can be partitioned into four structural domains. The function of the N-terminal domain, which is a target for serine-specific phosphorylation, has not been fully defined. The number of serine residues in the N-terminal domain of topoisomerase I from different species is inversely proportional to the number of charged amino acids in this region of the protein. The significance of this correlation is discussed in terms of a possible role for serine-specific phosphorylation in the activity of the enzyme.
