三羧酸循环代谢产物对人胎盘线粒体中孕酮生物合成的调节
Regulation of progesterone biosynthesis in human placental mitochondria by Krebs cycle metabolites.
作者信息
Klimek J, Boguslawski W, Tialowska B, Zelewski L
出版信息
Acta Biochim Pol. 1976;23(2-3):185-92.
PMID:970033
Abstract
- 2-Oxoglutarate, succinate, fumarate, malate and citrate, cis-aconitate and isocitrate stimulate conversion of cholesterol to progesterone in human placental mitochondria. 2. The stimulatory effect of dicarboxylic and tricarboxylic acids depends on the activity of malate dehydrogenase (decarboxylating) (NADP+) (EC 1.1.1.40) and isocitrate dehydrogenase (NADP+) (EC 1.1.1.42), respectively.
摘要
- 2-氧代戊二酸、琥珀酸、富马酸、苹果酸和柠檬酸、顺乌头酸和异柠檬酸可刺激人胎盘线粒体中胆固醇向孕酮的转化。2. 二羧酸和三羧酸的刺激作用分别取决于苹果酸脱氢酶（脱羧）（NADP+）（EC 1.1.1.40）和异柠檬酸脱氢酶（NADP+）（EC 1.1.1.42）的活性。
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