Kore-eda S, Horiguchi Y, Ueda M, Toda K, Imamura S
Department of Dermatology, Graduate School of Medicine, Kyoto University, Japan.
Am J Dermatopathol. 1998 Aug;20(4):362-9. doi: 10.1097/00000372-199808000-00007.
To detail the histogenetic relationship between basal cell carcinoma (BCC) and hair follicles, we immunohistochemically compared BCC cells to follicular matrix cells and follicular bulge cells using a panel of monoclonal antibodies against melanocytes, cytokeratins, subepidermal extracellular matrix components, and bullous pemphigoid (BP) sera, as well as using electron microscopy. Cytokeratin expression patterns were not consistent with the variety in types of cytokeratins and in cases of BCC. The distribution of some extracellular matrix components was not only linear along the interfaces of BCC tumor nests and stroma, and follicular matrix and follicular papilla; granular deposits were also seen in the stroma and follicular papilla, whereas they were only linearly distributed along the follicular bulge. The BP antigens and integrin alpha 6, which were absent in BCC and follicular matrix, were expressed in the follicular bulge area. Electron microscopically, hemidesmosomes were poorly organized in these three tissues, but the lamina densa was incomplete in BCC and follicular matrix, whereas the lamina densa in the follicular bulge area was continuous. These morphologic similarities between BCC and follicular matrix cells, and coexistence of melanocytes in the BCC tumor nest strongly suggest the differentiation of BCC toward the follicular matrix cells.
为详细阐述基底细胞癌（BCC）与毛囊之间的组织发生关系，我们使用一组针对黑素细胞、细胞角蛋白、表皮下细胞外基质成分和大疱性类天疱疮（BP）血清的单克隆抗体，并借助电子显微镜，对BCC细胞与毛囊基质细胞和毛囊隆突细胞进行了免疫组织化学比较。细胞角蛋白的表达模式与细胞角蛋白类型及BCC病例的多样性不一致。一些细胞外基质成分不仅沿BCC肿瘤巢与基质、毛囊基质与毛囊乳头的界面呈线性分布；在基质和毛囊乳头中也可见颗粒状沉积物，而它们仅沿毛囊隆突呈线性分布。BCC和毛囊基质中不存在的BP抗原和整合素α6在毛囊隆突区域表达。在电子显微镜下，这三种组织中的半桥粒组织不良，但BCC和毛囊基质中的致密板不完整，而毛囊隆突区域的致密板是连续的。BCC与毛囊基质细胞之间的这些形态学相似性，以及BCC肿瘤巢中黑素细胞的共存，强烈提示BCC向毛囊基质细胞分化。
