Charles A
Department of Neurology, UCLA School of Medicine, Los Angeles, California, USA.
Glia. 1998 Sep;24(1):39-49. doi: 10.1002/(sici)1098-1136(199809)24:1<39::aid-glia5>3.0.co;2-w.
Glial cells are capable of communicating increases in [Ca2+]i from a single cell to many surrounding cells. These intercellular Ca2+ waves have been observed in glia in multiple different preparations, including dissociated brain cell cultures, glial cell lines, organotypic brain slice cultures, and intact retinal preparations. They may occur spontaneously, or in response to a variety of stimuli. Ca2+ waves occurring under different conditions in different preparations may have distinctive patterns of initiation and propagation, and distinctive pharmacological characteristics consistent with the involvement of different intracellular and intercellular signaling pathways. This paper presents original data supporting a combination of gap junction and extracellular messenger-mediated signaling in mechanically induced glial Ca2+ waves. Additional new observations provide evidence that a rapidly propagated signal may precede the glial Ca2+ wave and may mediate rapid glial-neuronal communication. This original data is discussed in the context of a review of the literature and current concepts regarding the potential mechanisms, physiological and pathological roles of this dynamic pattern of glial intercellular signaling.
神经胶质细胞能够将单个细胞内[Ca2+]i的增加传递给许多周围细胞。在多种不同的制备物中，包括解离的脑细胞培养物、神经胶质细胞系、器官型脑片培养物和完整的视网膜制备物，都观察到了这些细胞间的Ca2+波。它们可能自发出现，也可能对多种刺激作出反应。在不同制备物中不同条件下出现的Ca2+波可能具有独特的起始和传播模式，以及与不同细胞内和细胞间信号通路参与相一致的独特药理学特征。本文提供了原始数据，支持在机械诱导的神经胶质细胞Ca2+波中缝隙连接和细胞外信使介导的信号传导相结合。另外的新观察结果提供了证据，表明一个快速传播的信号可能先于神经胶质细胞Ca2+波出现，并可能介导快速的神经胶质细胞 - 神经元通讯。本文在回顾文献以及关于这种动态神经胶质细胞间信号传导模式的潜在机制、生理和病理作用的当前概念的背景下讨论了这些原始数据。
