[毒毛旋花子苷和2,4-二硝基苯酚对东莨菪碱诱发大鼠皮层乙酰胆碱释放的影响]
[Influence of strophanthin and 2,4-dinitrophenol to the scopolamine-evoked acetylcholine release in rat cortex].
作者信息
Fischer H D, Scherber A, Staib A H
出版信息
Acta Biol Med Ger. 1976;35(3-4):485-90.
PMID:970053
Abstract
In rats narcotized by urethan we investigated the effect of 2,4-dinitrophenol and ouabain with regard to the cortical release of acetylcholine stimulated by scopolamine and to the acetylcholine content of telencephalon changed in that way. Dinitrophenol increased the liberating effect of scopolamine. In the presence of dinitrophenol and scopolamine ouabain reduced acetylcholine synthesis resulting in an strong decrease of acetylcholine content on persistent diminished increase of acetylcholine release.
摘要
在经乌拉坦麻醉的大鼠中，我们研究了2,4 -二硝基苯酚和哇巴因对东莨菪碱刺激引起的皮质乙酰胆碱释放以及由此导致的端脑乙酰胆碱含量变化的影响。2,4 -二硝基苯酚增强了东莨菪碱的释放作用。在存在2,4 -二硝基苯酚和东莨菪碱的情况下，哇巴因减少了乙酰胆碱的合成，导致乙酰胆碱含量大幅下降，而乙酰胆碱释放持续增加但增幅减小。
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