伏立康唑对曲霉属真菌的体外活性及其与伊曲康唑和两性霉素B的比较。
In-vitro activity of voriconazole against Aspergillus spp. and comparison with itraconazole and amphotericin B.
作者信息
Oakley K L, Moore C B, Denning D W
机构信息
Department of Medicine, University of Manchester School of Medicine, Hope Hospital, UK.
出版信息
J Antimicrob Chemother. 1998 Jul;42(1):91-4. doi: 10.1093/jac/42.1.91.
The in-vitro activity of the triazole antifungal agent voriconazole was compared with itraconazole and amphotericin B against 60 aspergillus isolates. Susceptibility tests were performed using two methods: a macrodilution and a microdulution method. For macrodilution methodology, geometric mean (GM) MIC values and ranges were 0.4 and 0.125-4 mg/L for voriconazole, 0.24 and 0.06-->16 mg/L for itraconazole, and 1.04 and 0.5-4 mg/L for amphotericin B. For the microdilution method, GM MICs and ranges were 0.66 and 0.125-2 mg/L for voriconazole, 0.27 and 0.06-->16 mg/L for itraconazole, and 1.62 and 0.25-32 mg/L for amphotericin B. In conclusion, voriconazole is active against Aspergillus spp. in vitro, and at similar concentrations to itraconazole.
将三唑类抗真菌药伏立康唑的体外活性与伊曲康唑和两性霉素B针对60株曲霉菌分离株进行了比较。采用两种方法进行药敏试验：常量稀释法和微量稀释法。对于常量稀释法，伏立康唑的几何平均（GM）MIC值及范围为0.4和0.125 - 4mg/L，伊曲康唑为0.24和0.06->16mg/L，两性霉素B为1.04和0.5 - 4mg/L。对于微量稀释法，伏立康唑的GM MIC值及范围为0.66和0.125 - 2mg/L，伊曲康唑为0.27和0.06->16mg/L，两性霉素B为1.62和0.25 - 32mg/L。总之，伏立康唑在体外对曲霉菌属具有活性，且活性浓度与伊曲康唑相似。
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