Mathison R, Lo P, Moore G, Scott B, Davison J S
Department of Physiology, Faculty of Medicine, University of Calgary, Alberta, Canada.
Peptides. 1998;19(6):1037-42. doi: 10.1016/s0196-9781(98)00048-5.
The effects of the submandibular gland peptide-T (SGP-T; Thr-Asp-Ile-Phe-Gly-Gly; TDIFEGG), its carboxy-terminal fragment (the tripeptide FEG; Phe-Glu-Gly), and the D-isomeric analog (feG) on intestinal and cardiovascular anaphylactic reactions were studied. The tripeptides, FEG and feG, when administered intravenously or orally to egg albumin-sensitized Hooded Lister or Sprague-Dawley rats 30 min prior to challenge with the antigen, totally prevented the disruption of intestinal motility and the development of anaphylaxis provoked diarrhea and inhibited anaphylactic hypotension by 66%. Submandibular gland peptides participate in the regulation of systemic inflammatory reactions, and the D-amino acid tripeptide, feG, is a potent, orally active anti-anaphylactic agent.
研究了颌下腺肽 -T（SGP -T；苏氨酸 - 天冬氨酸 - 异亮氨酸 - 苯丙氨酸 - 甘氨酸 - 甘氨酸；TDIFEGG）、其羧基末端片段（三肽FEG；苯丙氨酸 - 谷氨酸 - 甘氨酸）和D - 异构体类似物（feG）对肠道和心血管过敏反应的影响。在用抗原攻击前30分钟，将三肽FEG和feG静脉内或口服给予卵清蛋白致敏的带帽利斯特大鼠或斯普拉格 - 道利大鼠，可完全防止肠道运动紊乱以及过敏反应引发的腹泻，并使过敏性低血压降低66%。颌下腺肽参与全身炎症反应的调节，D - 氨基酸三肽feG是一种有效的口服活性抗过敏剂。
