Debeljuk L, Arce A, Garcia Bonacho M, Bartke A, Esquifino A I
Department of Physiology, Southern Illinois University School of Medicine, Carbondale 62901, USA.
Peptides. 1998;19(6):1073-8. doi: 10.1016/s0196-9781(98)00050-3.
In this investigation, the presence of NKA-immunoreactive substances was determined in pineal glands from intact, castrated and castrated, testosterone-treated male rats. The effect of environmental light, melatonin treatment and superior cervical ganglionectomy on pineal NKA-immunoreactive substances was also investigated. The results obtained show that NKA is present in measurable amounts in the rat pineal, and NPK is probably also present, Orchidectomy was followed by an increase in the content of NKA-immunoreactive substances in the pineal gland. The replacement treatment with testosterone propionate in castrated rats blocked this effect. NKA-immunoreactive substances were not significantly different quantitatively in pineals from rats killed under light or under darkness. The removal of the superior cervical ganglia was followed by a significant increase in the NKA-immunoreactive substance content in the pineal gland of male rats. These results indicate that NKA and other tachykinins are present in the pineal gland of the male rat, and they seem to be regulated by gonadal hormones and the innervation originated from the superior cervical ganglia.
在本研究中，测定了完整、阉割及阉割后经睾酮处理的雄性大鼠松果体中NKA免疫反应性物质的存在情况。还研究了环境光、褪黑素处理及颈上神经节切除术对松果体NKA免疫反应性物质的影响。所得结果表明，大鼠松果体中存在可测量量的NKA，并且可能也存在NPK。去势后松果体中NKA免疫反应性物质的含量增加。在阉割大鼠中用丙酸睾酮进行替代治疗可阻断这种作用。在光照或黑暗条件下处死的大鼠的松果体中，NKA免疫反应性物质在数量上无显著差异。切除颈上神经节后，雄性大鼠松果体中NKA免疫反应性物质的含量显著增加。这些结果表明，NKA和其他速激肽存在于雄性大鼠的松果体中，并且它们似乎受性腺激素和源自颈上神经节的神经支配的调节。
