Zoubek A, Kovar H, Gadner H
Forschungsinstitut für Krebskranke Kinder (CCRI), St. Anna Kinderspital, Wien.
Radiologe. 1998 Jun;38(6):467-71. doi: 10.1007/s001170050381.
Osteosarcoma, chondrosarcoma and tumors of the Ewing group are the most frequently observed primary malignant bone tumors. In an Internet homepage recently constructed for the Orthopedic Hospital Rizzoli Bologna, Italy, these tumors have represented the majority of 4423 malignant bone tumors in the archives of this institution since 1920 (http:/(/)www.tizeta.it/rizzoli). Malignant fibrous histiocytoma, fibrosarcoma, hemangioendothelioma, malignant hemangiopericytoma and giant-cell tumors are diagnosed less frequently. Since the introduction of modern molecular and cytogenetic techniques, knowledge of genetic aberrations in malignant bone tumors has steadily increased. However, so far only for the group of Ewing tumors has a recurrent chromosomal marker, the translocation t(11;22) (q24;q12), been identified.
骨肉瘤、软骨肉瘤和尤因氏肿瘤是最常见的原发性恶性骨肿瘤。在意大利博洛尼亚里佐利骨科医院最近创建的一个互联网主页上，自1920年以来，这些肿瘤在该机构档案中的4423例恶性骨肿瘤中占了大多数（http:/(/)www.tizeta.it/rizzoli）。恶性纤维组织细胞瘤、纤维肉瘤、血管内皮瘤、恶性血管外皮细胞瘤和巨细胞瘤的诊断频率较低。自现代分子和细胞遗传学技术问世以来，对恶性骨肿瘤基因畸变的认识不断增加。然而，到目前为止，仅在尤因氏肿瘤组中发现了一种复发性染色体标记，即易位t(11;22)(q24;q12)。
