Cook L L, Persinger M A
Neuroscience Laboratory, Laurentian University, Sudbury, Ontario, Canada.
Percept Mot Skills. 1998 Jun;86(3 Pt 2):1288-90. doi: 10.2466/pms.1998.86.3c.1288.
After training is an automated radial maze, 11 male rats were injected with either "subclinical" dosages of lithium and pilocarpine or saline and then tested 5 days or 4 months later. When employed as their own controls or when compared with a saline-injected reference group, the rats that had received the lithium and pilocarpine displayed memory deficits but not learning learning deficits after the longest of the two delays (effect size was 41%). These results suggest that subtle disruption in memory but not learning to criterion could be associated with "subclinical electrical seizures" or the micromorphological changes associated with this activity.
在经过自动放射状迷宫训练后，11只雄性大鼠被注射了“亚临床”剂量的锂盐和毛果芸香碱或生理盐水，然后在5天或4个月后进行测试。当将它们自身作为对照或与注射生理盐水的参照组进行比较时，接受锂盐和毛果芸香碱注射的大鼠在两个延迟时间中较长的那个之后表现出记忆缺陷，但没有学习缺陷（效应大小为41%）。这些结果表明，记忆方面的细微破坏而非达到标准的学习可能与“亚临床电惊厥”或与此活动相关的微观形态变化有关。
