Uitz E, Aglas F, Wurm A, Rainer F
Medizinischen Universitätsklinik Graz.
Wien Med Wochenschr. 1998;148(7):179-82.
This study investigated the efficacy and safety of a diclofenac/orphenadrin infusion in 21 female and 1 male patients with clinically and radiologically diagnosed inflammatory osteoarthritis of the big joints, especially the knee and hip joints. The patients received 1 infusion per day over 2 h for 10 days. Efficacy and safety were assessed by measuring the subjective pain intensity at rest and during exercise on a visual analogue scale and on an ordinal rating scale before and after every infusion. The patients were interviewed daily for possible side effects. After the 10-days treatment course a 5% reduction of pain at rest and a 37.5% reduction of pain during exercise was observed. Subjective pain intensity was reduced by an average of 32.5%. In most cases relief was noticeable after the 4th infusion. 9 patients rated the medication safety as "very good", 11 patients as "good". A total of 12 patients reported mainly mild side effects such as vertigo, dry mouth, and temporarily reduced visual acuity. Based on its rapid onset of action and its efficacy, it can be stated that the investigated diclofenac/orphenadrin infusion is a valuable extension of the therapeutic methods in patients with inflammatory osteoarthritis.
本研究调查了双氯芬酸/邻甲苯海明输注疗法对21名女性和1名男性患者的疗效及安全性，这些患者经临床和放射学诊断患有大关节（尤其是膝关节和髋关节）炎性骨关节炎。患者每天接受1次输注，持续2小时，共10天。在每次输注前后，通过视觉模拟量表和有序评定量表测量静息和运动时的主观疼痛强度，以此评估疗效和安全性。每天对患者进行访谈，询问是否有副作用。经过10天的治疗疗程，观察到静息时疼痛减轻5%，运动时疼痛减轻37.5%。主观疼痛强度平均降低32.5%。在大多数情况下，第4次输注后疼痛缓解明显。9名患者将药物安全性评为“非常好”，11名患者评为“好”。共有12名患者报告主要出现轻度副作用，如眩晕、口干和视力暂时下降。基于其快速起效和疗效，可以说所研究的双氯芬酸/邻甲苯海明输注疗法是炎性骨关节炎患者治疗方法的一个有价值的补充。
