Syntheses and calcium channel antagonist activity of nifedipine analogues with methylsulfonylimidazolyl substituent.
作者信息
Shafiee A, Dehpour A R, Hadizadeh F, Azimi M
机构信息
Department of Chemistry, Faculty of Pharmacy, Medical Sciences University of Tehran, Iran.
出版信息
Pharm Acta Helv. 1998 Jul;73(2):75-9. doi: 10.1016/s0031-6865(98)00004-1.
PMID:9700935
Abstract
Various diester analogues of nifedipine in which the ortho nitrophenyl group at position 4 is replaced by 1-methyl-2-methylsulfonyl-5-imidazolyl substituent, were synthesized and evaluated as calcium channel antagonists on guinea-pig ileal smooth muscle. Nifedipine was used as a standard. Compound 6n was found to be the most active.
摘要
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