Shafiee A, Dehpour A R, Hadizadeh F, Azimi M
Department of Chemistry, Faculty of Pharmacy, Medical Sciences University of Tehran, Iran.
Pharm Acta Helv. 1998 Jul;73(2):75-9. doi: 10.1016/s0031-6865(98)00004-1.
Various diester analogues of nifedipine in which the ortho nitrophenyl group at position 4 is replaced by 1-methyl-2-methylsulfonyl-5-imidazolyl substituent, were synthesized and evaluated as calcium channel antagonists on guinea-pig ileal smooth muscle. Nifedipine was used as a standard. Compound 6n was found to be the most active.
