The brain-specific S 100 protein in small cerebral stab wounds in the rat: a quantitative study.

A quantitative study of the changes in water-soluble proteins and water-soluble S 100 was made in stab-wounded rat frontal cortex as compared to unoperated controls. No great changes occurred until 30 days after the injury. At that time there was no change in the amount of water-soluble S 100 protein/g wet weight, but a large decrease in the amount of water-soluble proteins/g wet weight and thus a proportionate increase in the amount of water-soluble S 100 protein/mg of water-soluble proteins. The significance of the results is discussed.