Adcock P M, Sanders C L, Marshall G S
Division of Pediatric Infectious Diseases, Kosair Children's Hospital, Louisville, KY, USA.
Arch Pediatr Adolesc Med. 1998 Aug;152(8):739-44. doi: 10.1001/archpedi.152.8.739.
To study the effect of an educational intervention on the management of hospitalized infants with bronchiolitis.
Sequential, prospective cohort study.
A 235-bed children's hospital with nearly all private rooms.
Consecutively admitted, previously healthy children younger than 24 months with symptoms of bronchiolitis. The first cohort was enrolled between January 1 and January 21, 1996; the second cohort between January 29 and February 18, 1996, following a 1-week intervention period; the third (follow-up) cohort between December 1996 and February 1997.
Educational program and practice guidelines aimed at appropriate utilization of diagnostic tests, decreased antibiotic and bronchodilator use, increased compliance with isolation, decreased length of stay, and maintenance of quality care.
Utilization of respiratory syncytial virus (RSV) enzyme immunoassay, initiation and duration of parenteral antibiotic therapy, number of nebulized bronchodilator treatments, isolation orders, length of stay, and readmission rate.
A total of 90 patients were studied preintervention, 63 postintervention, and 90 during the follow-up period. The groups were comparable in demographic and clinical features. No patient had a documented serious bacterial infection; however, almost half in each group received parenteral antibiotics, despite recommendations against this. Immediately postintervention, children with positive RSV test results received antibiotics on fewer days than other children (median 0.6 vs 2.4 days; P=.004), suggesting that physicians stopped treatment with antibiotics once a viral diagnosis was confirmed. This effect did not persist into the follow-up period. Viral testing was reduced and isolation orders increased. Use of bronchodilators was reduced from 91% preintervention to 80% during the follow-up period (P=.046), and the median number of treatments was reduced from 15.0 to 10.0 (P=.005). There was no change in length of stay, which was 2 to 3 days, or in readmission rate, which was 1% to 4%.
Educational efforts centered around practice guidelines can improve some aspects of the treatment of patients hospitalized with bronchiolitis.
研究教育干预对住院毛细支气管炎婴儿治疗管理的影响。
序贯前瞻性队列研究。
一家拥有235张床位且几乎全为单人病房的儿童医院。
连续收治的年龄小于24个月、此前健康且有毛细支气管炎症状的儿童。第一队列于1996年1月1日至1月21日入组;第二队列于1996年1月29日至2月18日入组,此前有1周的干预期;第三(随访)队列于1996年12月至1997年2月入组。
教育项目及实践指南,旨在合理使用诊断检测、减少抗生素和支气管扩张剂的使用、提高隔离措施的依从性、缩短住院时间并维持优质护理。
呼吸道合胞病毒(RSV)酶免疫测定的使用情况、静脉用抗生素治疗的起始及持续时间、雾化吸入支气管扩张剂治疗的次数、隔离医嘱、住院时间及再入院率。
干预前共研究了90例患者,干预后63例,随访期间90例。各队列在人口统计学和临床特征方面具有可比性。无患者有确诊的严重细菌感染;然而,尽管有相关建议,每组中几乎一半的患者接受了静脉用抗生素治疗。干预后即刻,RSV检测结果呈阳性的儿童接受抗生素治疗的天数少于其他儿童(中位数分别为0.6天和2.4天;P = 0.004),这表明一旦确诊为病毒感染,医生就停止了抗生素治疗。但这种效果在随访期间未持续存在。病毒检测减少,隔离医嘱增加。支气管扩张剂的使用从干预前的91%降至随访期间的80%(P = 0.046),治疗次数的中位数从15.0次降至10.0次(P = 0.005)。住院时间(2至3天)和再入院率(1%至4%)无变化。
围绕实践指南开展的教育工作可改善住院毛细支气管炎患者治疗的某些方面。