Takahashi Y, Fuda H, Yanai H, Akita H, Shuping H, Chiba H, Matsuno K
Department of Pediatrics, Hokkaido University, Sapporo, Japan.
Semin Thromb Hemost. 1998;24(3):251-3. doi: 10.1055/s-2007-995850.
The significance of three platelet membrane glycoproteins, (CD62p, CD63, and CD36) was studied in platelet interaction with native and copper-oxidized plasma low-density lipoproteins (LDL). Native LDL acquired platelet-activating ability only after oxidation. Flow-cytometric studies showed that CD62P and CD63 were rapidly expressed on platelets at a low concentration of oxidized LDL, indicating that they are more sensitive markers than platelet aggregation for detection of platelet activation by oxidized LDL. CD36 was found to be contributing to the binding and activation of platelets with oxidized LDL, but not to the binding of platelets with native LDL. Although the presence of oxidized LDL in plasma is known, its effect on platelet function remains to be studied.
研究了三种血小板膜糖蛋白（CD62p、CD63和CD36）在血小板与天然及铜氧化血浆低密度脂蛋白（LDL）相互作用中的意义。天然LDL只有在氧化后才获得血小板激活能力。流式细胞术研究表明，在低浓度氧化LDL作用下，血小板上的CD62P和CD63迅速表达，这表明它们比血小板聚集更敏感，可用于检测氧化LDL诱导的血小板激活。发现CD36有助于血小板与氧化LDL的结合和激活，但对血小板与天然LDL的结合没有作用。虽然血浆中氧化LDL的存在是已知的，但其对血小板功能的影响仍有待研究。
