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High molecular mass dextran sulfate increases expression of HIV-1 coreceptor CCR-5 in macrophage-monocytes in culture.

作者信息

Jagodzinski P P, Trzeciak W H

机构信息

Department of Physiological Chemistry, University of Medical Sciences, Poznań, Poland.

出版信息

Acta Biochim Pol. 1998;45(1):241-4.

PMID:9701516
Abstract

It has been reported that high molecular mass dextran sulfate (HMDS) enhances the infection of monocyte-macrophages by HIV-1. We observed that in monocyte-macrophages maintained in the presence of HMDS the expression of HIV-1 coreceptor CCR-5 was increased approximately 5-fold at the transcriptional level. We postulate that the increased expression of CCR-5 might be responsible for HMDS-enhanced infectivity of monocyte-macrophages by HIV-1.

摘要

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