Larsen J K, Lindberg M L, Skovgaard B
Acta Psychiatr Scand. 1976 Sep;54(3):167-73. doi: 10.1111/j.1600-0447.1976.tb00109.x.
Twenty-six depressed patients, 19 of whom suffered from an endogenous depression, were sleep-deprived for one night, and eight of these were additionally sleep-deprived for three to nine nights with two sleep deprivations per week. While the sleep deprivation was being carried through, none of the patients were treated with tricyclic antidepressants. The patients were rated before and after the sleep deprivation(s). Sleep deprivation appeared to be effective for both unipolar and bipolar depressions. According to the rating scale an improvement was registered especially when the clinical picture was characterized by depressed mood, psycho-motor retardation and anxiety. As sleep deprivation cured 25% of the patients and further incidentally improved another 20% of the patients, it can be concluded that sleep deprivation seems to be a valuable treatment, especially in retarded endogenous depressions.
26名抑郁症患者，其中19名患有内源性抑郁症，被剥夺睡眠一晚，其中8名患者还被额外剥夺睡眠三至九晚，每周进行两次睡眠剥夺。在进行睡眠剥夺期间，所有患者均未接受三环类抗抑郁药治疗。在睡眠剥夺前后对患者进行评分。睡眠剥夺似乎对单相和双相抑郁症均有效。根据评分量表，尤其当临床表现为情绪低落、精神运动迟缓及焦虑时，可观察到病情改善。由于睡眠剥夺治愈了25%的患者，另外还意外改善了20%患者的病情，因此可以得出结论，睡眠剥夺似乎是一种有价值的治疗方法，尤其对于迟缓性内源性抑郁症。
