Nagaya T, Seo H
Department of Endocrinology and Metabolism, Nagoya University.
Nihon Rinsho. 1998 Jul;56(7):1861-5.
Thyroid hormone is essential for normal development and several metabolic pathways. Its action is mediated through its nuclear receptors (thyroid hormone receptors: TRs), which regulate gene transcriptions in a ligand-dependent manner. The abnormality of TR functions is linked with several disorders including resistance to thyroid hormone (RTH), malignancy and euthyroid sick syndrome. For example, mutant TRs were identified to cause RTH and a certain malignancy. The functionally impaired TRs might be related with euthyroid sick syndrome. The analyses of these TRs will elucidate the molecular mechanism or basis for the disorders, and may provide a new insight to find the way of diagnosis and treatment.
甲状腺激素对正常发育和多种代谢途径至关重要。其作用通过核受体（甲状腺激素受体：TRs）介导，TRs以配体依赖的方式调节基因转录。TR功能异常与多种疾病相关，包括甲状腺激素抵抗（RTH）、恶性肿瘤和正常甲状腺病态综合征。例如，已鉴定出突变的TRs可导致RTH和某种恶性肿瘤。功能受损的TRs可能与正常甲状腺病态综合征有关。对这些TRs的分析将阐明这些疾病的分子机制或基础，并可能为寻找诊断和治疗方法提供新的见解。
