Yamada M, Mori M
First Dept. of Internal Medicine, Gunma University, School of Medicine.
Nihon Rinsho. 1998 Jul;56(7):1931-7.
Thyrotropin-releasing hormone (TRH) receptor (TRHR) cDNAs have been cloned from several species since 1990. Sequence analysis of these cDNAs showed that TRHR belongs to the family of G-protein coupled receptors containing seven transmembrane domains. The human gene spans more than 30 kb and contains three exons and two introns, which located on chromosome 8q23. Several new evidences have been reported including primary structure of TRHRs, distribution of TRHR mRNA, three dimensional structure of the TRH binding pocket, structure of the TRHR gene promoter, G-proteins and TRHR etc. Furthermore, a patient with central hypothyroidism caused by compound mutations of the TRHR gene and a novel transcript of TRHR gene in the pituitary have been recently reported.
自1990年以来，促甲状腺激素释放激素（TRH）受体（TRHR）的cDNA已从多个物种中克隆出来。对这些cDNA的序列分析表明，TRHR属于含有七个跨膜结构域的G蛋白偶联受体家族。人类基因跨度超过30kb，包含三个外显子和两个内含子，位于8号染色体q23上。已经报道了一些新证据，包括TRHR的一级结构、TRHR mRNA的分布、TRH结合口袋的三维结构、TRHR基因启动子的结构、G蛋白和TRHR等。此外，最近还报道了一名因TRHR基因复合突变导致中枢性甲状腺功能减退的患者以及垂体中TRHR基因的一种新转录本。
