三倍剂量的钆喷酸葡胺可提高脊髓磁共振成像检测多发性硬化症强化病灶的敏感性。
Triple dose of gadolinium-DTPA increases the sensitivity of spinal cord MRI in detecting enhancing lesions in multiple sclerosis.
作者信息
Yousry T A, Fesl G, Walther E, Voltz R, Filippi M
机构信息
Department of Neuroradiology, Neurology Klinikum Grosshadern, University of Munich, Germany.
出版信息
J Neurol Sci. 1998 Jun 30;158(2):221-5. doi: 10.1016/s0022-510x(98)00114-2.
We compared the sensitivity of single and triple dose Gd-DTPA magnetic resonance imaging (MRI) in detecting enhancing lesions in the spinal cord of 13 patients with multiple sclerosis (MS). We detected two enhancing lesions in two of 13 (15%) patients when the single dose of Gd-DTPA was used and 12 lesions in five of 13 (38%) patients when the triple dose of Gd-DTPA was used. These results suggest that: (1) the use of triple dose increases the sensitivity of spinal cord MRI when studying relapsing-remitting or secondary progressive MS patients, (2) triple dose Gd-DTPA enhanced of the spinal cord MRI might be useful in monitoring disease activity in patients with MS.
我们比较了单剂量和三剂量钆喷酸葡胺磁共振成像（MRI）检测13例多发性硬化症（MS）患者脊髓强化病灶的敏感性。使用单剂量钆喷酸葡胺时，13例患者中有2例（15%）检测到2个强化病灶；使用三剂量钆喷酸葡胺时，13例患者中有5例（38%）检测到12个病灶。这些结果表明：（1）在研究复发缓解型或继发进展型MS患者时，使用三剂量可提高脊髓MRI的敏感性；（2）三剂量钆喷酸葡胺增强的脊髓MRI可能有助于监测MS患者的疾病活动。
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