[博尔纳病病毒——人类精神神经疾病的一种可能病原体？]

[Borna disease virus--a possible etiological agent of human psychoneurological disorders?].

作者信息

Prokudina E N, Kaverin N V

出版信息

Vopr Virusol. 1998 May-Jun;43(3):100-4.

Abstract

The characteristics of Borna disease virus are described, specifically, the structure and replicative features. This virus differs from other representatives of Mononegavirales order and therefore cannot be referred to any of its families. There are grounds to propose that Borna disease virus is the forefather of a new family: Bornaviridae. The review presents data on neurological and behavioral disorders caused by this virus in animals. A relatively high level of antiviral antibodies was detected in humans with mental disorders; moreover, virus antigens and virus RNA were found in the brain postmortem. Contribution of Borna disease virus to mental diseases of man is discussed.

摘要

本文描述了博尔纳病病毒的特征，特别是其结构和复制特性。该病毒与单股负链RNA病毒目其他成员不同，因此不能归属于该目的任何一个科。有理由提出博尔纳病病毒是一个新科——博尔纳病毒科的始祖。本文综述了该病毒在动物中引起的神经和行为障碍的数据。在患有精神障碍的人类中检测到相对较高水平的抗病毒抗体；此外，在死后大脑中发现了病毒抗原和病毒RNA。本文还讨论了博尔纳病病毒对人类精神疾病的影响。