Kano Y, Otake Y, Shiohara T
Department of Dermatology, Kyorin University School of Medicine, Tokyo, Japan.
J Am Acad Dermatol. 1998 Aug;39(2 Pt 2):305-8. doi: 10.1016/s0190-9622(98)70377-9.
Recently, a relationship between immunologic alterations and the development of lichen nitidus (LN) lesions has been described. We treated LN lesions with topical dinitrochlorobenzene (DNCB) application in a patient with peripheral CD4+ T lymphocytopenia. After 4 months, the eruption cleared. We investigated histologically and immunohistochemically biopsy specimens obtained before and after treatment. Our result suggests that local alterations of the pattern of cells and cytokines by topical DNCB application could have contributed to the resolution of the LN lesions.
最近，已有文献描述了免疫改变与光泽苔藓（LN）皮损发生之间的关系。我们对一名外周血CD4+ T淋巴细胞减少的患者采用外用二硝基氯苯（DNCB）治疗LN皮损。4个月后，皮疹消退。我们对治疗前后获取的活检标本进行了组织学和免疫组化研究。我们的结果表明，外用DNCB导致的细胞和细胞因子模式的局部改变可能促使了LN皮损的消退。
