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茶碱对淋巴细胞磷酸二酯酶活性的影响。

Effects of theophylline on lymphocyte phosphodiesterase activity.

作者信息

Tohda Y, Nakahara H, Kubo H, Ohkawa K, Fukuoka M, Nakajima S

机构信息

Fourth Department of Internal Medicine, Kinki University School of Medicine, Osakasayama, Osaka, Japan.

出版信息

Gen Pharmacol. 1998 Sep;31(3):409-13. doi: 10.1016/s0306-3623(98)00027-5.

DOI:10.1016/s0306-3623(98)00027-5
PMID:9703210
Abstract
  1. To clarify part of the bronchodilating effects of theophylline, lymphocyte cyclic AMP (cAMP) and phosphodiesterase (PDE) activity in asthmatic patients and healthy adults were measured. 2. No clear differences in lymphocyte PDE activity were found regarding sexes, ages or the types of asthma. 3. Lymphocyte PDE activity in the asthma group was significantly higher than that in the control group. 4. Lymphocyte cAMP significantly increased at 30 and 60 min after intravenous injection of aminophylline in the asthma group. 5. Lymphocyte PDE activity significantly decreased 60 min after intravenous injection of aminophylline in the asthma group.
摘要
  1. 为阐明茶碱的部分支气管扩张作用，对哮喘患者和健康成年人的淋巴细胞环磷酸腺苷（cAMP）及磷酸二酯酶（PDE）活性进行了测定。2. 在性别、年龄或哮喘类型方面，未发现淋巴细胞PDE活性有明显差异。3. 哮喘组的淋巴细胞PDE活性显著高于对照组。4. 哮喘组静脉注射氨茶碱后30分钟和60分钟时，淋巴细胞cAMP显著增加。5. 哮喘组静脉注射氨茶碱60分钟后，淋巴细胞PDE活性显著降低。

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引用本文的文献

1
Identification and quantification of phosphodiesterase 4 subtypes in CD4 and CD8 lymphocytes from healthy and asthmatic subjects.健康和哮喘受试者CD4和CD8淋巴细胞中磷酸二酯酶4亚型的鉴定与定量分析。
Br J Pharmacol. 2001 Jul;133(5):722-9. doi: 10.1038/sj.bjp.0704120.