肝脏烟酰胺N-甲基转移酶活性增加作为荷结肠26腺癌小鼠癌症恶病质的标志物。
Increased hepatic nicotinamide N-methyltransferase activity as a marker of cancer cachexia in mice bearing colon 26 adenocarcinoma.
作者信息
Okamura A, Ohmura Y, Islam M M, Tagawa M, Horitsu K, Moriyama Y, Fujimura S
机构信息
Department of Biochemistry, Chiba University School of Medicine.
出版信息
Jpn J Cancer Res. 1998 Jun;89(6):649-56. doi: 10.1111/j.1349-7006.1998.tb03267.x.
When a cachexigenic subclone (clone 20) of murine colon 26 adenocarcinoma was transplanted into female BALB/c mice, hepatic NNMT activity continued to increase until death in proportion to progressive carcass weight loss, a marker of cancer cachexia. On the other hand, noncachexigenic subclone (clone 5)-transplanted mice showed neither increase of NNMT activity nor carcass weight loss. Among cytostatic fluorinated pyrimidines, 5'-dFUrd could inhibit the increase of NNMT activity and prevent weight loss in mice bearing clone 20. On the other hand, 2'-dFUrd did not show these effects. 5-FUra and Tegafur inhibited the increase of NNMT activity at higher concentrations. These findings suggest that the levels of hepatic NNMT activity are closely associated with the degree of weight loss, and they appear to be a useful marker of cancer cachexia.
当将小鼠结肠26腺癌的恶病质亚克隆（克隆20）移植到雌性BALB/c小鼠体内时，肝脏NNMT活性持续增加，直至小鼠死亡，其增加比例与渐进性体重减轻成正比，而体重减轻是癌症恶病质的一个标志。另一方面，移植了非恶病质亚克隆（克隆5）的小鼠既未出现NNMT活性增加，也未出现体重减轻。在具有细胞抑制作用的氟化嘧啶中，5'-dFUrd可抑制携带克隆20的小鼠的NNMT活性增加，并防止体重减轻。另一方面，2'-dFUrd未表现出这些作用。5-FUra和替加氟在较高浓度下可抑制NNMT活性增加。这些发现表明，肝脏NNMT活性水平与体重减轻程度密切相关，它们似乎是癌症恶病质的一个有用标志。
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