Friedrich M, Riffel B, Schillinger H, Schweizer J, Mink D, Reitnauer K, Helpap B, Schmidt W
Universitäts-Frauenklinik mit Poliklinik und Hebammenlehranstalt Homburg/Saar.
Zentralbl Gynakol. 1998;120(7):341-6.
Leiomyosarcoma are malignant tumors showing smooth muscle differentiation, they are rare, representing only about 25 percent of all uterine sarcomas and mixed malignant tumors and slightly more than 1 percent of all corporeal malignant tumors. Usually they arise in postmenopausal women and are not known to be related to the known risk factors for endometrial carcinoma (nulliparity, obesity, diabetes mellitus, hypertension, etc.) or carcinosarcoma (prior radiation therapy). They may occur in uteri that also bear typical benign leiomyomas, but leiomyosarcoma rarely can be proven to have arisen in or from benign leiomyomas. We report on two premenopausal women with leiomyosarcoma--out of totally 31 cases in our clinic from 1975-1995 who got pregnant after surgical treatment preserving the uterus. The patients are alive without evidence of disease 3 and 6 years after surgical resection.
平滑肌肉瘤是表现出平滑肌分化的恶性肿瘤，较为罕见，仅占所有子宫肉瘤和混合性恶性肿瘤的约25%，占所有实体恶性肿瘤的略多于1%。通常发生于绝经后女性，与已知的子宫内膜癌风险因素（未生育、肥胖、糖尿病、高血压等）或癌肉瘤（既往放疗史）无关。它们可能出现在同时伴有典型良性平滑肌瘤的子宫中，但很少能证实平滑肌肉瘤起源于良性平滑肌瘤。我们报告了两名患有平滑肌肉瘤的绝经前女性——在我们诊所1975年至1995年的31例病例中，她们在保留子宫的手术治疗后怀孕。手术切除后3年和6年，这两名患者均存活且无疾病迹象。
