Hoffmann R, Melcher I, Wichelhaus A, Haas N P
Universitätsklinikum-Charité, Humboldt-Universität zu Berlin, Germany.
Anticancer Res. 1998 May-Jun;18(3C):2243-9.
Breast cancer is an osteotropic primary tumor. For the patient metastases to the skeleton imply functional restriction with immobility and pain. Unlike other primary carcinomas breast cancer shows a distinctly longer life expectancy after occurrence of skeletal filiae. LOTE even states a mean survival rate of 4 years. Impending or manifest pathologic fractures as well as pain refractory to medication therapy are indications for operative treatment. As a function of the estimated life expectancy, the number and localisation of metastases and possible adjuvant therapy (hormonal or chemotherapy, radiotherapy) the operative procedure must be chosen. Available options are' intramedullary stabilizing procedures, compound osteosynthesis or endoprothetic means. The objective is the restitution of the weight bearing capacity of the affected skeletal region in addition to pain reduction. This leads to early function and mobility and improves the patient's quality of life.
乳腺癌是一种亲骨性原发性肿瘤。对于患者而言，发生骨转移意味着功能受限，出现行动不便和疼痛。与其他原发性癌不同，乳腺癌在出现骨转移后预期寿命明显更长。长期骨转移（LOTE）甚至表明平均生存率为4年。即将发生或已出现的病理性骨折以及药物治疗难以缓解的疼痛是手术治疗的指征。根据预期寿命、转移灶的数量和位置以及可能的辅助治疗（激素或化疗、放疗）来选择手术方式。可用的选择包括髓内稳定手术、复合骨固定术或假体植入术。目标是除减轻疼痛外，恢复受影响骨骼区域的负重能力。这可实现早期功能恢复和活动能力改善，并提高患者的生活质量。
