Sakurai K, Hata S, Amano S, Kimura T, Hori A, Sakamoto A, Kimizuka K, Mimatsu K, Nishio S, Miyake H, Shibata M, Fukuzawa M
1st Dept. of Surgery, Nihon University School of Medicine.
Gan To Kagaku Ryoho. 1998 Jul;25(9):1269-72.
We evaluated the clinical significance of p53, p27 and PCNA expressions in esophageal squamous cell carcinomas. Operative specimens obtained from 70 patients with esophageal squamous cell carcinomas were investigated by staining with antibodies against p53, p27 and PCNA. The correlations among p53, p27 and PCNA expression, clinicopathologic factors and prognosis were studied. The expression of p53 was observed in 55.7%, and it did not correlate to histologic classification, growth pattern, and lymphatic invasion. The expression of p27 was observed in 48.6%, and it correlated to lymph node metastasis. The PCNA positive index (PCNA-PI) was high in the p27 negative cases. The p53 positive and p27 negative group revealed the worst survival rate among groups. Therefore, the p27 positive case, often associated with well differentiated carcinoma, tends to have a slower tumor-growth rate and better prognosis. It is suggested that immunohistochemical assessment on the p53 and p27 expressions would be useful to the recognize the malignant potential and differentiation of squamous cell carcinoma of the esophagus.
我们评估了p53、p27和增殖细胞核抗原（PCNA）在食管鳞状细胞癌中的表达的临床意义。采用抗p53、p27和PCNA抗体染色，对70例食管鳞状细胞癌患者的手术标本进行研究。研究了p53、p27和PCNA表达、临床病理因素与预后之间的相关性。观察到p53表达率为55.7%，其与组织学分类、生长方式及淋巴浸润均无相关性。观察到p27表达率为48.6%，其与淋巴结转移相关。在p27阴性病例中增殖细胞核抗原阳性指数（PCNA-PI）较高。p53阳性且p27阴性组的生存率在各分组中最差。因此，p27阳性病例常与高分化癌相关，其肿瘤生长速度往往较慢且预后较好。提示对p53和p27表达进行免疫组化评估有助于认识食管鳞状细胞癌的恶性潜能和分化程度。
