Takahashi Y, Yamamoto N, Deguchi T, Kuriyama M, Yoh M, Yasuda M, Nakano M, Kawada Y, Takeuchi T, Shinoda I
Dept. of Urology, Gifu University School of Medicine.
Gan To Kagaku Ryoho. 1998 Jul;25(9):1310-3.
A clinical study was performed on the efficacy of intraarterial chemotherapy using reservoir system for far-advanced urological malignancy. The reservoir system was indwelled in the femoral subcutaneous layer using Seldinger's method. Fifteen cases with inoperable complicated advanced bladder cancer and ten cases with postoperative local recurrent bladder cancer received intraarterial chemotherapy using the reservoir system. Then, 23 cases with local relapsed prostate cancer and two cases with endocrine-resistant prostate cancer received chemotherapy. The administered anti-cancerous agents were methotrexate, cis-platinum and adriamycin, and 5-FU or carboplatin were administered as maintenance therapy. The mean courses of chemotherapy were six for bladder cancer and four for prostate cancer. During stabilization of the local lesion, no distant deterioration was recognized. Overall clinical efficacy was as follows: PR:18 cases and NC:7 cases for bladder cancer; then, PR:11 cases and 14 cases for prostate cancer. The median duration of stabilization was as follows: 23 months for bladder cancer and 12 months for prostate cancer. Complications were fewer than with systemic chemotherapy.
对使用储药系统进行动脉内化疗治疗晚期泌尿系统恶性肿瘤的疗效进行了一项临床研究。采用Seldinger法将储药系统留置在股部皮下层。15例无法手术的复杂性晚期膀胱癌患者和10例术后局部复发性膀胱癌患者接受了使用储药系统的动脉内化疗。然后，23例局部复发前列腺癌患者和2例内分泌抵抗性前列腺癌患者接受了化疗。给药的抗癌药物为甲氨蝶呤、顺铂和阿霉素，5-氟尿嘧啶或卡铂作为维持治疗给药。膀胱癌化疗的平均疗程为6个疗程，前列腺癌为4个疗程。在局部病灶稳定期间，未发现远处病情恶化。总体临床疗效如下：膀胱癌PR：18例，NC：7例；前列腺癌PR：11例，NC：14例。稳定期的中位持续时间如下：膀胱癌为23个月，前列腺癌为12个月。并发症比全身化疗少。
