Hakawa S K, Kouda K, Tanaka Y
Dept. of Radiology, Kansai Medical University.
Gan To Kagaku Ryoho. 1998 Jul;25(9):1352-4.
The concentration of hepatocyte growth factor (HGF) was increased immediately after transcatheter arterial embolization (TAE) for hepatocellular carcinoma (HCC). We measured the changes in serum HGF levels and those of the asialoglyco-protein receptors (ASGP) in hepatocytes using 99mTc-galactosyl human serum albumin (GSA) on 22 patients with HCC after TAE. HGF and Rmax were increased 33% +/- 32, 40% +/- 28, respectively. Effects of HGF administration were examined in normal rats. Liver weight, hepatocyte nuclear size, and number of hepatocytes (cells/mm2) were not altered by HGF, but GSA blood clearance per hepatocyte was significantly increased over the preinfusion rate. We conclude that increased HGF stimulates a hepatocytic function of the receptor-mediated uptake of ASGP.
肝细胞生长因子（HGF）的浓度在经动脉导管栓塞术（TAE）治疗肝细胞癌（HCC）后立即升高。我们使用99mTc-半乳糖基人血清白蛋白（GSA）对22例TAE术后的HCC患者测量了血清HGF水平以及肝细胞中去唾液酸糖蛋白受体（ASGP）水平的变化。HGF和Rmax分别升高了33%±32、40%±28。在正常大鼠中检测了HGF给药的效果。HGF未改变肝脏重量、肝细胞核大小和肝细胞数量（细胞/mm2），但每个肝细胞的GSA血液清除率较输注前显著增加。我们得出结论，升高的HGF刺激了受体介导的ASGP摄取的肝细胞功能。
