Shonai T, Hareyama M, Sakata K, Oouchi A, Nagakura H, Koito K, Morita K, Satoh M, Asakura K, Kataura A, Hinoda Y
Department of Radiology, Sapporo Medical University, School of Medicine, Japan.
Jpn J Clin Oncol. 1998 May;28(5):339-42. doi: 10.1093/jjco/28.5.339.
Most laryngeal cancers are squamous cell carcinomas, and adenocarcinomas account for < 1% of cancers of the larynx. Among them, mucoepidermoid carcinoma is extremely rare and there is little agreement about the treatment of this carcinoma. We encountered one patient with mucoepidermoid carcinoma of the bilateral vocal cords (T1bN0M0, Stage 1). For this, most investigators recommended a surgical procedure. However, because of his old age, the early stage and low grade of histopathology, we treated this patient with radiotherapy alone, delivered by accelerated hyperfractionation, which is a more effective strategy for treating radioresistant tumors than conventional irradiation. Following radiotherapy, the tumor disappeared and the patient has been alive and well for more than six years. An old patient with mucoepidermoid carcinoma of the larynx was successfully treated with radiotherapy alone.
大多数喉癌是鳞状细胞癌,腺癌占喉癌的比例不到1%。其中,黏液表皮样癌极为罕见,对于这种癌的治疗几乎没有共识。我们遇到一名双侧声带黏液表皮样癌患者(T1bN0M0,1期)。对此,大多数研究者推荐手术治疗。然而,由于患者年龄较大、组织病理学分期早且分级低,我们仅对该患者进行了加速超分割放疗,与传统照射相比,这是治疗放射抗拒性肿瘤更有效的策略。放疗后,肿瘤消失,患者已存活六年多且状况良好。一名老年喉黏液表皮样癌患者仅通过放疗就成功治愈。