Volm M, Koomägi R, Mattern J
Department of Oncological Diagnostics and Therapy, German Cancer Research Center, Heidelberg, Germany.
Anticancer Res. 1998 Jul-Aug;18(4A):2309-12.
The analysis attempted to determine whether the expression of p16INK4A has prognostic relevance for patients with lung adenocarcinomas. For this purpose, immunohistochemistry was used to analyze 58 adenocarcinomas. Of the tumors investigated, 20 did not express p16INK4A, while 38 yielded a positive staining result. Median survival time was shorter for patients with p16INK4A negative carcinomas than for those with p16INK4A positive tumors (47 vs. 79 weeks, P = 0.11). The relative risk for patients with p16INK4A negative tumors was increased by a factor of 1.6 in comparison to positively stained tumors. There exists a direct correlation between the proportion of G0/G1 phase cells and the p16INK4A expression. Additionally, there is an inverse relationship between S phases and p16INK4A expression. Furthermore, p16INK4A negative adenocarcinomas show more frequent growth in nude mice than p16INK4A positive carcinomas.
该分析试图确定p16INK4A的表达对肺腺癌患者是否具有预后相关性。为此，采用免疫组织化学方法分析了58例腺癌。在所研究的肿瘤中，20例不表达p16INK4A，而38例染色结果为阳性。p16INK4A阴性癌患者的中位生存时间短于p16INK4A阳性肿瘤患者（47周对79周，P = 0.11）。与染色阳性的肿瘤相比，p16INK4A阴性肿瘤患者的相对风险增加了1.6倍。G0/G1期细胞比例与p16INK4A表达之间存在直接相关性。此外，S期与p16INK4A表达之间存在负相关关系。此外，p16INK4A阴性腺癌在裸鼠中的生长比p16INK4A阳性癌更频繁。
